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Sildenafil is commonly used in Viagra, while pentoxifylline is a vasodilator that may help increase blood flow when applied to the skin.29 One early study found that sildenafil cream increased genital and self-reported measures of arousal compared to placebo cream in a group of six women, which is promising but obviously a very small sample.8 More recent research on topical sildenafil suggests it may help some women, particularly those with arousal-specific concerns, though it didnt show clear benefits across the full study population.41 The good news is that sildenafil cream appears to be well tolerated in clinical trials, with few reported side effects.17 Overall, formulations combining sildenafil and pentoxifylline may help with certain arousal-related symptoms, but the research is still in its infancy and the evidence isnt especially robust

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